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0 -1.1116 TD
[(lar)12.7(ge)-418.1(ef)14(fec)11.7(ts,)-414.5(wh)14.2(en)-418.1(com)11.6(par)12.8(ed)-412.3(wit)12.8(h)-421.6(c)0(o)13.9(ntr)13.9(ol)-417(con)12.8(dit)13.7(ion)13.8(s,)-413.3(and)]TJ
T*
[(the)12.7(y)-214.2(cou)12.8(ld)-203.9(be)-210.7(an)-210.7(eff)12.9(ect)11.5(iv)15(e)-215.4(cho)12.8(ice)-207.3(for)-204.8(cl)13.8(ini)13.7(cia)11.5(ns)-209.4(and)-206.1(pat)12.7(ie)13.8(nts)14(.)]TJ
7.3823 0 0 6.5614 293.7826 258.2928 Tm
(12)Tj
9.843 0 0 9.843 62.022 242.929 Tm
[(How)12.2(eve)11.7(r,)-211.8(no)-209.5(art)12.7(icl)12.6(e)-215.4(ana)11.7(lyz)12.7(ed)-210.7(in)-209.7(the)-206.2(rev)12.8(iew)11.8(s)-214(men)11.6(tio)13.7(ned)-206.1(abo)12.8(ve)]TJ
T*
[(foc)12.8(use)13(d)-421.6(o)0(n)-416.9(p)0(a)13.9(tie)12.6(nts)-412.2(wit)12.8(h)-421.6(car)11.7(dia)12.7(c)-417(dis)14(eas)11.8(es.)-415.5(Th)13.9(is)-416.8(gap)-413.4(in)-417(the)]TJ
T*
[(lit)13.6(era)11.7(tur)13.9(e)-215.4(the)12.7(ref)12.9(ore)-211.8(pro)14(mpt)12.6(ed)-210.7(thi)13.7(s)-219.8(stu)14(dy,)-207.2(whi)13(ch)-216.5(eva)17.4(lua)12.7(ted)-211.9(how)]TJ
0 -1.1174 TD
[(VR)-269(the)12.7(rap)12.8(y)-266(aff)12.9(ect)11.5(ed)-268.3(the)-258(int)13.7(ens)13(ity)-262.7(of)-267.1(dep)12.8(res)13(siv)14(e)-267.2(sym)13(pto)13.9(ms)-268.2(as)]TJ
0 -1.1116 TD
[(wel)11.8(l)-375.6(a)0(s)-371.8(anx)12.8(iet)12.6(y)-375.5(and)-367.3(str)14.1(ess)-366.9(lev)12.7(els)-367.3(in)-370.9(CAD)-368.9(pat)12.7(ien)12.7(ts)-370.8(who)-367(had)]TJ
T*
[(und)14(erg)12.8(one)-286.7(CR.)]TJ
/F4 1 Tf
8.9663 0 0 8.9663 62.022 166.2236 Tm
[(Materials)-332.7(and)-338.2(Methods)]TJ
/F10 1 Tf
0 -1.84 TD
[(Design)-335(and)-335.7(participants)]TJ
/F5 1 Tf
9.843 0 0 9.843 72 133.285 Tm
[(The)-362.8(stu)14(dy)-370.8(was)-368(co)13.9(ndu)14(cte)11.5(d)-375.5(a)0(t)-366.4(a)-376.6(car)11.7(dia)12.7(c)-370.9(cli)12.6(nic)12.7(,)-372(whi)13(ch)-372(pro)14(-)]TJ
-1.0137 -1.1116 TD
[(vid)13.8(ed)-418.1(the)-413.5(sec)11.8(ond)-412.2(sta)12.9(ge)-418.1(of)-422.6(CR)13(.)-423.9(Bas)12(ed)-418.1(on)-422.7(Wh)12.8(ite)12.6(hea)11.7(d)-421.6(e)0(t)-418.2(al.)]TJ
0 -1.1174 TD
[(sam)11.8(ple)-309.9(siz)12.9(e)-324.8(for)-308.5(a)-319(pil)13.7(ot)-319.1(ran)12.8(dom)18.5(ize)11.5(d)-323.6(tri)13.8(al)-314.5(gui)13.8(del)12.7(ine)18.4(,)-320.2(the)-315.6(stu)14(dy)]TJ
0 -1.1116 TD
[(inc)12.7(lud)13.9(ed)-268.3(34)-261.4(pat)12.7(ien)12.7(ts.)]TJ
7.3823 0 0 6.5614 143.6598 104.7685 Tm
(15)Tj
9.843 0 0 9.843 153.6377 100.4031 Tm
[(The)-264.8(stu)14(dy)-261.4(was)-264.3(des)13(ign)13.8(ed)-268.3(as)-262.4(a)-273(par)12.8(all)12.6(el-)]TJ
-9.3077 -1.1116 TD
[(gro)14(up)-203.8(RCT)-202.4(\(Fi)14(g.)-200.4(1\).)-201.4(The)-201.5(des)13(ign)-199.3(fol)13.9(low)13(s)-208.2(the)-200.4(rec)11.7(om)13.9(men)11.6(dat)12.7(ion)13.8(s)]TJ
0 -1.1174 TD
[(for)-320(th)15(e)-330.6(sec)11.9(ond)-314.3(pha)12.8(se)-319.9(\(VR)12.1(2\))-324.7(of)-318.9(cli)12.6(nic)12.7(al)-320.3(tri)13.8(als)-315.4(in)-324.9(hea)17.4(lth)-320.3(usi)14(ng)]TJ
0 -1.1116 TD
[(VR,)-433.8(foc)12.8(usi)14(ng)-439.9(on)-439.9(acc)10.5(ept)12.7(ab)13.9(ili)13.6(ty,)-437.7(fea)11.7(sib)14(ili)19.4(ty,)-437.7(tol)13.7(era)11.7(bil)13.7(it)14.8(y,)-442.3(and)]TJ
T*
[(ini)13.7(tia)12.6(l)-260.4(cli)12.6(nic)12.7(al)-256.9(ef)13(ca)12.8(cy.)]TJ
7.3823 0 0 6.5614 152.2771 60.9449 Tm
(16)Tj
9.843 0 0 9.843 162.1984 56.5795 Tm
[(Pat)18.6(ien)12.7(ts)-255.6(wer)12(e)-261.4(ran)12.8(dom)12.8(ly)-255.8(ass)13.2(ign)13.8(ed)-256.8(to)]TJ
15.3266 67.9242 TD
[(rec)11.7(eiv)12.7(e)-497.6(C)0(R)-493.8(com)11.6(bin)13.8(ed)-492.9(wit)12.8(h)-496.4(eig)12.7(ht)-491.9(ses)13.2(sio)14(ns)-491.6(of)-491.7(VR)-493.7(the)12.7(rap)12.9(y)]TJ
0 -1.1174 TD
[(\(in)13.9(ter)12.7(ven)12.8(tio)13.7(n)-340.9(gro)14(up,)]TJ
/F6 1 Tf
8.3689 0 TD
(n)Tj
/F7 1 Tf
.6624 0 TD
(=)Tj
/F5 1 Tf
.7142 0 TD
[(17\))14(,)-337.5(con)12.8(duc)12.8(ted)-332.9(tw)14.1(ice)-334.1(a)-342.1(wee)10.8(k)-335.2(for)-331.5(20)]TJ
-9.7454 -1.1116 TD
[(min)12.6(ute)12.7(s,)-447.8(or)-451.4(CR)-453.5(co)13.9(mbi)12.6(ned)-448(wit)12.8(h)-450.4(eig)12.7(ht)-451.6(ses)13.2(sio)14.1(ns)-451.3(of)-445.7(sta)12.9(nda)12.8(rd)]TJ
T*
[(rel)12.7(axa)11.7(tio)13.7(n)-594.3(tec)11.5(hni)13.8(que)]TJ
7.3823 0 0 6.5614 396.1133 696.6423 Tm
(17)Tj
9.843 0 0 9.843 409.3227 692.277 Tm
[(\(co)12.8(nt)14.9(rol)-590.9(gro)14(up)15.1(,)]TJ
/F6 1 Tf
6.8886 0 TD
(n)Tj
/F7 1 Tf
.6624 0 TD
(=)Tj
/F5 1 Tf
.7142 0 TD
[(17\))14(,)-596.7(c)0(o)13.9(ndu)14(cte)11.5(d)]TJ
-18.0452 -1.1116 TD
[(twi)12.8(ce)-206.1(a)-203.8(wee)10.8(k)-202.7(for)-199.1(20)-198(min)12.6(ute)12.7(s.)-200.2(Tab)11.6(le)-199.3(1)-208.4(pre)12.8(sen)13(ts)-198(pat)12.7(ien)12.7(t)-202.8(bas)13(eli)12.6(ne)]TJ
0 -1.1174 TD
[(cha)11.7(rac)11.7(ter)12.7(ist)13.9(ics)12.9(.)-326(Stu)14(dy)-319(at)13.8(ten)12.7(dan)12.8(ce)-321.3(was)-316.2(ent)12.7(ire)12.7(ly)-319.1(vol)13.8(unt)13.8(ary)12.8(,)-320.2(the)]TJ
0 -1.1116 TD
[(pat)12.7(ien)12.7(ts)-295.9(pro)19.8(vid)13.9(ed)-297.1(wri)13(tt)14.8(en)-297.1(con)12.8(se)14.1(nt)-296.1(to)-290.3(par)12.8(tic)12.6(ipa)12.7(te)-291.5(and)-286.7(wer)12(e)-296(in-)]TJ
T*
[(for)14(med)-293.7(bef)12.8(ore)18.6(han)12.8(d)-300.6(tha)12.7(t)-295(the)12.7(y)-300.6(cou)18.6(ld)-296.1(lea)11.5(ve)-291.3(the)-292.6(pro)14(gra)18.6(m)-301.8(a)0(t)-291.5(any)]TJ
0 -1.1174 TD
[(giv)13.9(en)-377.7(mo)13.9(men)11.6(t,)-373.3(wit)12.8(hou)14(t)-375.6(con)12.8(seq)13(ue)13.9(nce)11.7(s)-381(t)0(o)-370.9(the)12.7(ir)-370.9(cli)12.6(nic)12.7(al)-372.1(car)11.7(e.)]TJ
0 -1.1116 TD
[(The)-489.5(stu)14(dy)-491.8(was)-489(gra)12.9(nte)12.7(d)-496.4(e)0(t)13.8(hic)12.7(al)-493.1(app)12.8(rov)14(al)-493.1(by)-491.8(the)-482.6(Sci)12.8(ent)12.7(ic)]TJ
T*
[(Res)12(ear)11.7(ch)-343.2(Eth)12.7(ics)-338.5(Com)11.7(mit)12.5(tee)-339.8(\(re)12.9(fer)12.9(en)13.9(ce)-344.3(num)12.7(ber)12.9(:)-346.8(31/)13.8(201)14(9\))-342(at)]TJ
0 -1.1174 TD
[(the)-304.1(Uni)18.7(ver)12.8(sit)13.9(y)-312.1(o)0(f)-301.7(Phy)14.1(sic)12.9(al)-303(Edu)12.8(cat)17.3(ion)-302.9(in)-301.8(Wro)11.7(cl)13.8(aw,)-301.4(Pol)14(and)-298.2(in)]TJ
0 -1.1116 TD
[(Jun)14.2(e)-296(201)14(9)-294.8(\(NC)12.1(T04)12.8(045)14(977)14(\).)]TJ
1.0137 -1.1116 TD
[(Inclusion)-402.8(criteria)-404.3(were)-399.2(as)-400.6(follows:)-401.5(CAD)-397.7(patients)-403(under-)]TJ
-1.0137 -1.1116 TD
[(going)-501(the)-499.9(second)-504.1(stage)-497.3(of)-497.5(CR)-499.6(in)-503.4(ambulatory)-498.6(conditions,)]TJ
0 -1.1174 TD
[(anxie)-8(ty)-480.4(symptom)-488.2(scores)-486.6(of)-480.2(8)-484.9(and)-482.5(higher)-485.9(in)-486.1(the)-482.6(Hospital)]TJ
0 -1.1116 TD
[(Anxiety)-614.8(and)-609.2(Depression)-612.9(Scale)-608(\(HADS\),)-611.4(HADS-Anxiety)]TJ
T*
[(\(HADS-)-9(A\))-302.5(or)-307.4(depressive)-308(symptoms)-310.5(scoring)-308.3(8)-306.4(and)-304(higher)-307.4(in)]TJ
0 -1.1174 TD
[(HADS,)-609.3(HADS-Depression)-609.4(\(HADS-D\),)-608.7(and)-603.5(aged)-605.7(6080.)]TJ
0 -1.1116 TD
[(Exclusion)-438.6(criteria)-438.8(were)-439.5(as)-429.4(follows:)-436.1(cognitive)-438.8(impairments)]TJ
T*
[(preventing)-457.1(self-completion)-453.5(of)-451.4(research)-450.9(questionnai)-8.9(res,)-451.2(the)]TJ
0 -1.1174 TD
[(presence)-393.4(of)-382.3(the)-384.7(following)-385.5(issues)-381.7(at)-389.4(the)-379(time)-387.2(of)-382.3(the)-384.7(exami-)]TJ
0 -1.1116 TD
[(nation)-618.6(or)-606.9(in)-612.9(the)-615.1(medical)-617.5(records:)-615.8(disturbances)-615.6(of)-612.7(con-)]TJ
T*
[(sciousness,)-436.6(psychotic)-438.5(symptoms,)-434.9(bipolar)-429.6(disorder)-436.1(or)-434.1(other)]TJ
0 -1.1174 TD
[(serious)-359.9(psychiatric)-361.4(disorders,)-359.8(initiation)-358.5(of)-353.5(psychiatric)-361.4(treat-)]TJ
0 -1.1116 TD
[(ment)-231.6(or)-232.6(individual)-231.6(psychological)-231.1(therapy)-234.8(during)-225.6(the)-229.2(research)]TJ
T*
[(project,)-336.2(contraindications)-340.6(for)-331.5(virtual)-331.8(therapy)-332.7(\(epilepsy,)-338.2(ver-)]TJ
T*
[(tigo,)-336.4(eyesight)-333.8(impairment\),)-337.4(and)-332.8(the)-332.9(patients)-334.9(refusal)-332.5(to)-336.4(par-)]TJ
0 -1.1174 TD
[(ticipate)-306.6(at)-303(any)-298.2(stage)-307.3(of)-295.9(the)-304.1(research)-307(project.)]TJ
/F10 1 Tf
8.9663 0 0 8.9663 313.0582 390.8408 Tm
[(Outcome)-337.1(measures)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 374.3999 Tm
[(As)-342.7(a)-347.8(primary)-344.2(outcome)-345.5(measure,)-343.9(HADS)-346.7(was)-345(used.)-342.9(It)-342.1(is)-342(a)]TJ
-1.0137 -1.1174 TD
[(14-item)-258(scale)-262.4(scoring)-256.4(from)-253.2(0)-254.5(t)0(o)-255.8(3)-254.5(for)-256.7(each)-255.6(item.)-258.2(Seven)-255.3(items)]TJ
0 -1.1116 TD
[(related)-483.7(to)-474.6(anxiety)-476.8(\(HADS-A\),)-476.3(while)-474.3(the)-476.9(remaining)-480.2(seven)]TJ
T*
[(related)-299.4(to)-296.1(depression)-301(\(HADS-D\).)-297.7(The)-293.6(global)-296(scoring)-296.8(ranged)]TJ
0 -1.1174 TD
[(from)-224.4(0)-225.7(t)0(o)-227(42,)-218.7(with)-224.4(a)-226.9(cutoff)-226.7(point)-224.6(of)-221(8/21)-223.4(for)-227.9(anxiety,)-226.8(and)-223.3(8/21)]TJ
0 -1.1116 TD
[(for)-297(depression.)-304.5(The)-293.6(higher)-301.6(the)-298.3(score,)-299(the)-292.6(greater)-299.2(the)-298.3(anxiety)]TJ
T*
[(or)-330.5(depression)-329.8(symptoms.)]TJ
7.3823 0 0 6.5614 412.8377 313.0015 Tm
(18)Tj
9.843 0 0 9.843 423.4393 308.6361 Tm
[(According)-330(to)-330.6(the)-327.1(authors,)-329(Cron-)]TJ
-11.2141 -1.1116 TD
[(bachs)-285.2(alpha)-284.4(ranges)-279.4(from)-282(0.78)-283.2(to)-278.8(0.93)-277.4(for)-285.5(the)-281.1(HADS-A,)-284.1(and)]TJ
0 -1.1174 TD
[(from)-362.7(0.82)-358.1(to)-359.4(0.90)-358.1(for)-360.3(the)-361.7(HADS-D,)-358.9(and)-361.6(test/retest)-361.4(correla-)]TJ
0 -1.1116 TD
[(tions)-305.1(were)]TJ
/F6 1 Tf
4.4983 0 TD
(r)Tj
/F7 1 Tf
.5529 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
(0.80.)Tj
7.3823 0 0 6.5614 389.5369 280.1196 Tm
(19)Tj
9.843 0 0 9.843 323.0361 264.8125 Tm
-.0156 Tc
[(As)-327.5(a)-323.1(s).8(eco)-15.6(n)11(d).6(ary)-327.7(outco)-15.6(m)9.8(e)-323.1(measu)-15.6(r)11(e,)-324.3(the)-323.1(P)-15.6(e)10(r).6(cep)-15.6(t)10.9(i).4(on)-322(o)-15.6(f)-311.5(Str)-15.6(e)9.9(ss)]TJ
-1.0137 -1.1174 TD
-.0159 Tc
[(Q)-15.9(u)9.8(est)-15.9(i)10.4(onn)-15.9(a)9.5(i).1(re)-242.8(\(PS)-15.9(Q)10(\))-241.6(w)-.6(as)-241.4(use)-15.9(d)9.5(.)-238.2(T)-.9(hi)-15.9(s)-225.4(q)-15.9(u)10.7(e)-.9(st)-15.9(i)10.4(onna)-15.9(i)9.4(r).3(e)-242.8(w)-.6(as)-241.4(cre)-15.9(a)8.4(ted)]TJ
0 -1.1116 TD
[(b)-15.9(y)-231.2(P)-15.9(l)10.7(opa)-248.6(an)-15.9(d)-231.2(M)-.6(a)-15.9(k)9.5(arow)-15.9(s)10(k).3(i)-247.5(a)-.9(nd)-247.4(is)-247.2(a)-248.6(27-)-15.9(i)10.6(t).2(em)-248.6(sca)-15.9(l)9.4(e,)-244(s)-15.9(c)9.7(ori)-15.9(n)10.6(g)-247.4(from)]TJ
T*
-.0156 Tc
[(1)-229.8(t).5(o)-229.8(5)-229.8(for)-229.8(ea)-15.6(c)8.7(h)-229.8(item.)]TJ
7.3823 0 0 6.5614 389.1967 236.296 Tm
-.0162 Tc
(20)Tj
9.843 0 0 9.843 398.5511 231.9306 Tm
-.0155 Tc
[(Twen)-15.5(t)11(y-o)-15.5(n)11.1(e)-230.9(items)-229.5(ex)-15.5(a)9.9(m)-.5(ined)-229.7(th)-15.5(e)-214.7(l)-15.5(e)9.8(v).7(el)-229.8(of)]TJ
-8.6856 -1.1174 TD
-.0158 Tc
[(s)-15.8(t)10.9(re)-15.8(s)9.8(s)-402.6(in)-402.8(th)-15.8(e)-393.5(a)-.8(rea)-15.8(s)-393.3(of)-402.8(emot)-15.8(i)10.5(ona)-15.8(l)-393.7(t).2(ens)-15.8(i)10.9(on,)-405.1(ext)-15.8(e)9.5(rnal)-402.9(s)-15.8(t)10.9(r).4(es)-15.8(s)11.2(,)-405.1(and)]TJ
0 -1.1116 TD
0 Tc
[(in)26.5(t)16.1(r)16.2(ap)25.4(s)16.4(y)16.2(ch)25.4(i)16.1(c)-342.1(s)16.4(t)16(re)25.5(s)16.4(s)16.4(,)-343.2(a)15(n)16.2(d)-340.9(6)-340.9(i)16.1(t)16.1(e)0(m)24.2(s)-335(re)25.5(f)16.2(e)15(rr)26.7(e)15(d)-340.9(t)16.1(o)-340.9(t)16.1(h)16.2(e)-342.1(l)16.1(ie)-326(sc)25.6(a)15(l)16.1(e)15(.)-343.2(T)15(h)16.2(e)]TJ
T*
-.016 Tc
[(g)-16(l)10.5(oba)-16(l)-330.5(s)-16(c)9.6(ori)-16(n)10.5(g)-345.4(for)-345.4(th)-16(e)-330.4(p)-16(e)9.4(r).2(cep)-16(t)10.5(i).1(on)-345.4(of)-345.4(s)-16(t)10.7(res)-16(s)-328.8(r)-16(a)9.5(nge)-16(d)-330.4(f)-16(r)10.7(o).2(m)-346.6(2).2(1)-345.4(t).1(o)]TJ
0 -1.1174 TD
-.0158 Tc
[(1)-15.8(0)10.8(5,)-289.9(wi)-15.8(t)10.5(h)-287.6(a)-288.8(c)-15.8(u)9.6(t).3(of)-15.8(f)-277.1(p).4(o)-15.8(i)10.7(nt)-287.7(o)-15.8(f)-277.2(60)-293.4(for)-293.3(eleva)-15.8(t)9.5(ed)-287.6(l)-15.8(e)9.5(vels)-293.2(of)-293.3(perce)-15.8(i)9.5(ved)]TJ
0 -1.1116 TD
-.0161 Tc
[(s)-16.1(t)10.6(re)-16.1(s)9.5(s).3(.)-416.9(T)-1.1(he)-415.8(h)-16.1(i)10.4(ghe)-16.1(r)-405.3(t)0(he)-415.8(s)-16.1(c)9.5(ore)-16.1(,)-401.9(t)-16.1(h)10.4(e)-415.8(gr)-16.1(e)9.4(a)-1.1(ter)-420.3(t)0(he)-415.8(s)-16.1(e)9.5(nse)-415.8(o)-16.1(f)-404.2(s).3(tr)-16.1(e)9.4(s).3(s)-16.1(.)]TJ
T*
0 Tc
[(Ac)24.6(c)15(o)16.2(rd)26.6(i)16.1(n)16.2(g)-283.3(t)16.1(o)-283.3(t)16.1(h)16.2(e)-284.5(a)15(u)16.2(t)16.1(h)0(o)26.6(r)16.2(s,)-269.3(C)15.2(r)16.2(o)16.2(n)0(b)26.6(a)15(c)15(h)16.2(s)-266.9(al)25.3(p)16.2(h)16.2(a)-284.5(f)16.2(o)16.2(r)-283.3(t)16.1(h)0(e)-268.3(i)16.1(nd)26.6(i)16.1(v)16.2(id)26.5(u)16.2(a)15(l)]TJ
T*
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